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authorization, and data integrity. Applications use DCE s Cell Directory Services for naming and location services. The extent of the linkage between DCE s offerings and Oracle applications is left to the architect. The application can use the full range of services, including authenticated RPC, single sign-on, naming, location, and security services or can use a minimal subset of services (for example, only implementing authentication by using the DCE generic security services API). Once a principal authenticates to the DCE cell that contains the database, the principal can access the database. Principals authenticated in this manner can also transfer an external role, defined through membership of a DCE group, into an internal Oracle database role. This feature enables the role-based authorization mechanisms within the database to be transparently enforced on the principal. Directory Services. As is becoming increasingly common with vendor products, Oracle supports integration with X.500 directories that use LDAP to provide enterprise user management. We will discuss enterprise security management using directories in 13. Oracle provides its own LDAP-compliant directory, Oracle Internet Directory, but also interacts with Microsoft Active Directory. Incidentally, X.500 directories and Kerberos are both key components of the Windows 2000 security architecture. Directories define user and resource hierarchies, domain-based user management, and distributed services such as naming, location, and security. Directories will increasingly play a critical role in addressing security challenges.

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Marcia Angell, a respected former editorin-chief of The New England Journal of Medicine and author of a book castigating the pharmaceutical industry, The Truth About the Drug Companies, has said Still, the FDA and Temple held firmly for placebos, for the most part Another hotly debated aspect of defining adequate and wellcontrolled involves how many different dosages of the drug should be tested Temple said the FDA tries to prod companies to experiment with a variety, to improve the chance of finding the optimum balance between potency and side effects However, if a study expands into multiple thousands of subjects, Temple conceded, that gets pretty daunting, and the FDA may not press the point In which case, probably just the higher doses, not lower ones, will be tested, because those are more likely to show strong results Dr Jay S.

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When we are building the thousandth identical unit in a housing development, plans can specify precisely how the foundation should be poured, where studs should be placed, where nails should be driven, and so on Because we have built this particular type of house so frequently, few surprises remain In fact, in such a situation, we would be remiss not to plan in great detail, since these details will help avoid leaving things to chance Projects with high levels of uncertainty, in contrast, cannot support this degree of detailed planning, because there is insuf cient information on how things will proceed Consider a project aimed at nding a cure for cancer The researchers undertaking this project have very little idea of what they will nd How they carry out their work depends, to a large extent, on their step-by-step discoveries, so their project plan must be rather vague and imprecise.

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Cohen, a physician and author of the 2001 book Over Dose, is probably the most prominent critic of the whole issue of dosage He charges that after testing at the higher levels, the pharmaceutical industry rarely ratchets down to try less potent amounts The danger of a too-high dose, as the blood-clot medicine TPA showed, is that it might cause serious side effects In a study of nearly 500 drugs approved.

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June 12, 2004

Good planning here may mean phased planning For example, a high-risk two-year project may be broken into six planning phases, with detailed planning initially undertaken only for phase 1 (months one through four) Toward the end of phase 1, detailed planning commences for phase 2, and so on This method is sometimes called the rolling wave approach to planning To force project staff on a highly uncertain project to develop sophisticated, detailed plans for the whole project is an exercise in futility We should bear in mind an important distinction between complexity and uncertainty I have had participants in my project management seminars ask, How can you say that there are low levels of uncertainty in building houses and bridges Even a routine bridge is highly complex and lled with uncertainty..

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